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Syntopix

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Publications

The Syntopix business is based upon world-class research in the fields of skin microbiology, antibiotic resistance in skin bacteria and Staphylococcus aureus as well as the pathobiology of acne and eczema. Publications of this research include:

2010

Novel insights into the antibacterial activity and mechanism of action of the lipophilic antioxidant tert-butylhydroquinone (TBHQ).
N. Ooi1, I. Chopra1, A. Eady2, J. Cove2, A. J. O'Neill1.
1University of Leeds, UK. 2Syntopix Group plc, UK.
Interscience Conference on Antimicrobial Agents and Chemotherapy Meeting, 12 Sept – 15 Sept 2010, Boston. Poster Presentation.

2009

Antimicrobial activity of 2-tert-butylhydroquinone (TBHQ) and bismuth or copper, new synergistic combinations for the treatment of acne.
Fitzgerald DJ, Gottardello P, Seville S, Eady EA, Cove JH.
American Association of Dermatology Summer Meeting, 29 Jul – 2 Aug 2009, Boston. Poster 101.
View electronic poster

Heme oxygenase-1: an overlooked potential target in inflammatory skin disease?
Burrill W, Eady EA, Cove JH.
American Association of Dermatology Summer Meeting, 29 Jul – 2 Aug 2009, Boston. Poster 400.
View electronic poster

TBHQ represents a new class of antibacterial for topical applications in dermatology.
Fitzgerald DJ, Qureshi A, Cove JH.
American Association of Dermatology Summer Meeting, 29 Jul – 2 Aug 2009, Boston. Poster 402.
View electronic poster

2007

Temporal changes in sebum excretion and propionibacterial colonization in preadolescent children with and without acne.
Mourelatos K, Eady EA, Cunliffe WJ, Clark SM, Cove JH.
Br J Dermatol. 2007 Jan;156(1):22-31.
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2006

Efficacy of oral isotretinoin in the control of skin and nasal colonization by antibiotic-resistant propionibacteria in patients with acne.
Coates P, Vyakrnam S, Ravenscroft JC, Stables GI, Cunliffe WJ, Leyden JJ, Johnson J, Eady EA, Cove JH.
Br J Dermatol. 2005 Dec;153(6):1126-36. Erratum in: Br J Dermatol. 2006 Apr;154(4):807.
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2005

ABC proteins and antibiotic drug resistance: is it all about transport?
Kerr ID, Reynolds ED, Cove JH.
Biochem Soc Trans. 2005 Nov;33 (Pt 5):1000-2.
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Enhanced resistance to erythromycin is conferred by the enterococcal msrC determinant in Staphylococcus aureus.
Reynolds E, Cove JH.
J Antimicrob Chemother. 2005 Feb;55(2):260-4. Epub 2005 Jan. 13
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2004

Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial
Ozolins M, Eady EA, Avery AJ, Cunliffe WJ, Po AL, O'Neill C, Simpson NB, Walters CE, Carnegie E, Lewis JB, Dada J, Haynes M, Williams K, Williams HC.
Lancet. 2004 Dec 18-31;364(9452):2188-95.
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2003

Short-term effects of topical fusidic acid or mupirocin on the prevalence of fusidic acid resistant (FusR) Staphylococcus aureus in atopic eczema.
Ravenscroft JC, Layton AM, Eady EA, Murtagh MS, Coates P, Walker M, Cove JH.
Br J Dermatol. 2003 May;148(5):1010-7.
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Msr(A) and related macrolide/streptogramin resistance determinants: incomplete transporters?
Reynolds E, Ross JI, Cove JH.
Int J Antimicrob Agents. 2003 Sep;22(3):228-36.
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Correlation between enterococcal biofilm formation in vitro and medical-device-related infection potential in vivo.
Sandoe JA, Witherden IR, Cove JH, Heritage J, Wilcox MH.
J Med Microbiol. 2003 Jul;52(Pt 7):547-50.
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Cytolysin gene expression in Enterococcus faecalis is regulated in response to aerobiosis conditions.
Day AM, Cove JH, Phillips-Jones MK.
Mol Genet Genomics. 2003 Apr;269(1):31-9.
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